Abcam, ab174437, Anti-L2/HNK-1 Carbohydrate antibody [ZN-12]

Size: 100µg
Mouse Monoclonal L2/HNK-1 Carbohydrate antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 1 publication.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:zn-12,
Isotype:IgG1,
Light chain type:kappa,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.

Product details:
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Properties and Storage Information:
Form-Liquid, Purity-undefined SDS-PAGE, Purification notes-ab174437 is produced in vitro using hybridomas grown in serum-free medium, and then concentrated by chemical fractionation. Near homogeneity as judged by SDS-PAGE., Storage buffer-pH: 7.5Preservative: 0.02% Sodium azideConstituents: 99.9% HEPES buffered saline, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
L2/HNK-1 Carbohydrate also known as CD57 antigen is a glycan structure recognized for its role in cell-cell interaction processes. This carbohydrate moiety has a distinct structure that includes sulfated glucuronic acid followed by a linear poly-N-acetyllactosamine. It usually appears in the nervous system as well as certain subsets of immune cells especially on natural killer (NK) and T lymphocytes. The molecular mass of the L2/HNK-1 carbohydrate is complex due to its glycosylation making exact mass variable depending on the glycoprotein or glycolipid to which it is attached.
Biological function summary
L2/HNK-1 Carbohydrate participates in neural cell recognition and migration assisting in neurodevelopmental processes. It is not part of a single complex; instead it interacts with multiple proteins and cell surface molecules contributing to signal transduction involved in synaptic stabilization and regeneration. This carbohydrate also plays a role in modulating immune cell activities and is considered important in identifying specific subpopulations of T and NK cells.
Pathways
L2/HNK-1 Carbohydrate belongs to key processes such as the cell adhesion and signal transduction pathways. It shares interactions with proteins involved in the neural cell adhesion molecule (NCAM) pathway facilitating synaptic plasticity and neuronal connectivity. Its involvement in immune pathways connects it to lectin proteins influencing T cell activation and immune response modulation.
Abnormal expression or dysfunction of L2/HNK-1 Carbohydrate relates to conditions like multiple sclerosis and certain cancers. It is associated with neurodegenerative processes where changes in its expression can affect neuronal repair and immune functions. In cancer particularly in certain lymphomas altered levels of CD57 antigen can indicate tumor infiltration by NK cells and T lymphocytes reflecting its engagement with immune regulatory proteins such as CD8.