Abcam, ab174657, Anti-ZPR9 antibody

Size: 100µg
Rabbit Polyclonal ZPR9 antibody. Suitable for IP, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human ZNF622 aa 100-200.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human ZNF622 aa 100-200. The exact immunogen used to generate this antibody is proprietary information.Q969S3

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab174657 was affinity purified using an epitope specific to ZPR9 immobilized on solid support., Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: 99% Tris citrate/phosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ZPR9 also known as Zinc Finger Protein of Unknown Function 9 is a nuclear protein with a molecular mass of approximately 60 kDa. It contains zinc finger domains which serve as key structural motifs for binding to DNA. ZPR9 is expressed in various tissues including liver and brain but shows a higher expression in immune cells. It functions through specific DNA interactions regulating the transcriptional activity of several genes involved in cell growth and immune response.
Biological function summary
ZPR9 plays a role in managing cellular processes that include transcriptional regulation and cellular signaling. It often associates with other proteins to form complexes that modulate gene expression in response to external stimuli. Research has shown that ZPR9 interacts with components of the transcription machinery influencing numerous biological functions that encompass immune system modulation and cell cycle progression.
Pathways
ZPR9 contributes significantly to the MAPK signaling pathway and NF-kB pathway. In the MAPK pathway it connects with proteins such as ERK1/2 impacting cellular responses like proliferation and differentiation. In the NF-kB pathway ZPR9 has links with protein p65 contributing to the regulation of immune responses and inflammation. These connections indicate its integration in key signaling networks vital for cellular homeostasis and immune regulation.
ZPR9 correlates with autoimmune diseases and cancer. Its abnormally high expression in conditions like rheumatoid arthritis suggests roles in inflammatory processes. Moreover alterations in ZPR9 expression have association with cancer development where it may impact tumor growth and metastasis. In autoimmune conditions it interacts with other proteins including NF-kB showing its influence on inflammatory pathways and potential as a therapeutic target.