Abcam, ab174832, Anti-LINGO4 antibody [EPR12600]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal LINGO4 antibody. Suitable for IP, WB and reacts with Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR12600,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purity-Tissue culture supernatant, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
LINGO4 also known as Leucine Rich Repeat and Ig domain containing 4 is a protein with a mass of approximately 78 kDa. This protein is part of the LRR transmembrane protein family and plays an important role as a modulator in the nervous system. Expression of LINGO4 is detected in the central nervous system particularly in neural tissues. The protein's structure includes leucine-rich repeats that facilitate protein-protein interactions.
Biological function summary
LINGO4 functions as an important regulator in neural development and axon formation. It interacts with other proteins such as the Nogo receptor forming multiprotein complexes that influence neuronal growth. Through these complexes LINGO4 negatively regulates nerve regeneration and neuronal survival impacting the growth and maintenance of the nervous system. This regulation is essential during neural maturation and response to injury.
Pathways
LINGO4 plays a significant role in neuronal signaling pathways such as the Nogo receptor signaling pathway and the myelin inhibitory signaling pathway. In these pathways LINGO4 interacts with other proteins like NOGO and p75 neurotrophin receptor modulating neuronal growth inhibition. These interactions and pathways are vital for controlling neural plasticity and regeneration impacting the nervous system's ability to recover from damage.
LINGO4's function is connected to neurological conditions including multiple sclerosis and spinal cord injuries. Altered expression or dysfunction of LINGO4 can impair neural repair processes contributing to disease pathology. In disorders like multiple sclerosis the protein's interaction with the Nogo receptor and the myelin-associated glycoprotein pathways plays a pivotal role in modulating the immune responses and neuronal damage influencing disease progression and patient outcomes.