Abcam, ab174845, Anti-MFAP4 antibody [EPR10255]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal MFAP4 antibody. Suitable for WB and reacts with Human, Mouse, Rat samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR10255,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purity-Tissue culture supernatant, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
MFAP4 also known as Microfibril-Associated Glycoprotein 4 is a protein that plays a significant role in the extracellular matrix architecture. The molecular mass of MFAP4 is about 29 kDa. This protein is expressed in various tissues including the lung liver heart and blood vessels. As a part of the extracellular matrix MFAP4 contributes to the structural integrity and elasticity of connective tissues.
Biological function summary
MFAP4 interacts with components of the microfibrillar network. It is not a standalone entity but functions as part of a larger complex that includes elastin and microfibrillin-1. This association enhances the mechanical properties of tissues maintaining them against pressure and stretch forces. MFAP4 also participates in cellular responses such as cell adhesion and migration which are critical for tissue remodeling and repair processes.
Pathways
MFAP4 engages in multiple biological pathways related to the extracellular matrix and tissue homeostasis. The TGF-beta signaling pathway is notable as MFAP4 interacts with multiple proteins within this pathway such as fibrillin-1. Through these interactions MFAP4 influences the regulation of cell growth and differentiation. Another pathway is the integrin signaling pathway where its association with integrins supports cell adhesion and communication within the extracellular matrix.
MFAP4 shows associations with fibrosis and chronic obstructive pulmonary disease (COPD). Both conditions involve alterations in the extracellular matrix composition and function. In fibrosis the dysregulated expression of MFAP4 can affect connective tissue remodeling. Altered MFAP4 levels have also been observed in COPD where it may impact lung tissue elasticity. The protein connects with TGF-beta in the context of these diseases influencing abnormal tissue remodeling and inflammation processes.