Abcam, ab176701, Anti-TBC1D2 antibody - N-terminal

Size: 100µL
Rabbit Polyclonal TBC1D2 antibody. N-terminal. Suitable for IP, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human TBC1D2 aa 1-50.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human TBC1D2 aa 1-50. The exact immunogen used to generate this antibody is proprietary information.Q9BYX2

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 6.8 - 7.4Preservative: 0.09% Sodium azideConstituents: 99% Tris buffered saline, 0.1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TBC1D2 also known as Armus is a protein involved in tethering and trafficking of endosomes exhibiting a molecular mass of approximately 120 kDa. It interacts with Rab7 a small GTPase to regulate the elongation of endosomal structures. Expression of TBC1D2 is found in many tissues with significant levels in the brain and adipose tissue. The protein functions as a GAP (GTPase-activating protein) facilitating the conversion of Rab7-GTP to Rab7-GDP which is an important process in endosomal transport and maturation.
Biological function summary
TBC1D2 plays a role in the regulation of cellular autophagy and endocytosis. It is part of the endosomal complex involved in cargo sorting and trafficking affecting the lysosomal degradation pathway. The interaction with Rab7 suggests its involvement in the fusion of late endosomes with lysosomes. Additionally TBC1D2 regulates actin cytoskeleton dynamics by modulating signal transduction pathways impacting various cellular processes such as cell migration and morphogenesis.
Pathways
TBC1D2 participates in the endocytic and autophagic pathways influencing cellular homeostasis and response to stress. In the endocytic pathway it works closely with proteins like Rab7 to modulate endosome maturation. TBC1D2 also intersects with other autophagic-related proteins impacting cellular recycling processes important for maintaining cellular environment stability and responding to nutrient availability.
TBC1D2 is linked to neurodegenerative and metabolic conditions. Aberrant regulation of its activity is associated with Alzheimer’s disease affecting amyloid precursor protein processing and clearance. Moreover TBC1D2's involvement in adipose tissue function connects it to obesity-related disorders influencing body weight and metabolism. Its interactions with proteins like Rab7 in these disease contexts underline its critical role in cellular trafficking and metabolic regulation.