Abcam, ab176817, Anti-WDR3 antibody

Size: 100µL
Rabbit Polyclonal WDR3 antibody. Suitable for IP, WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human WDR3 aa 200-300.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human WDR3 aa 200-300. The exact immunogen used to generate this antibody is proprietary information.Q9UNX4

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab176817 was affinity purified using an epitope specific to WDR3 immobilized on solid support., Storage buffer-pH: 6.8 - 7.4Preservative: 0.09% Sodium azideConstituents: 99% Tris buffered saline, 0.1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
WD repeat domain 3 also known as WDR3 is a protein consisting of a series of WD repeat motifs. The protein weighs approximately 67 kDa and is mainly expressed in multiple tissues including the heart lung and liver. Mechanically WDR3 serves as a component of ribosomal biosynthesis. It interacts with other proteins to assist the assembly of ribosomal subunits participating in the nucleolar processing of pre-18S ribosomal RNA.
Biological function summary
WDR3 plays an essential role in the formation and maturity of ribosomes. It forms part of the ribonucleoprotein complex aiding in the production of ribosomal RNA which is critical for protein synthesis. Through its interaction with other proteins WDR3 facilitates the transport and processing of key nucleolar components maintaining cellular function. Its presence in the nucleolus suggests its involvement in cell growth and division linking it to fundamental cellular processes.
Pathways
WDR3 closely engages with the ribosome biogenesis pathway contributing significantly to the creation of functional ribosomes. It also associates with the p53 signaling pathway indicating its role in cell cycle regulation and apoptosis. Proteins such as NOP56 and UTP14A share connections with WDR3 within these pathways often co-regulating ribosomal gene transcription and processing activities.
WDR3 has potential implications in cancer due to its involvement in cell cycle and growth regulation. Altered expression of WDR3 can contribute to tumorigenesis by affecting ribosome production and cellular proliferation. Additionally defects in WDR3 function may relate to Diamond-Blackfan anemia a disorder characterized by failure in red blood cell production. Here its association with ribosomal protein genes like RPS19 points to its significance in hematopoietic tissue homeostasis.