Abcam, ab177239, Anti-FUT2 antibody

Size: 200µL
Goat Polyclonal FUT2 antibody. Suitable for WB and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human FUT2 aa 1-50.
Key facts
Host species:Goat,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human FUT2 aa 1-50. The exact immunogen used to generate this antibody is proprietary information.Q10981

Product details:
Reported variants represent identical protein: NP_001091107.1, NP_000502.4.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab177239 is purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide., Storage buffer-pH: 7.3Preservative: 0.02% Sodium azideConstituents: 99% Tris buffered saline, 0.5% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The FUT2 gene encodes the enzyme fucosyltransferase 2 also known as alpha-(12) fucosyltransferase. This enzyme plays an important role in the attachment of fucose a type of sugar to the H antigen precursor on cell surfaces facilitating the formation of H antigen. FUT2 has a molecular mass of approximately 39 kDa and is predominantly expressed in the epithelial tissues such as salivary glands intestines and lungs. Its expression allows it to influence the glycosylation process which is important for proper cell signaling and communication.
Biological function summary
Fucosylated glycoproteins and glycolipids generated by FUT2 take part in host-pathogen interactions. This enzyme does not form part of a larger complex but exerts its activity as an individual glycosyltransferase. The products of FUT2 are significant in processes like cell adhesion and recognition particularly in the gastrointestinal tract where it determines the secretion of ABO blood group antigens into bodily fluids. These secretor status antigens act as receptors for bacteria and viruses influencing susceptibility to infections.
Pathways
The fucosylation process mediated by FUT2 integrates into glycosylation pathways. The fucosylated antigens are also part of the larger context of N-glycan biosynthesis. FUT1 another fucosyltransferase is related to FUT2 through shared function in synthesizing fucosylated structures although FUT1 operates more in erythrocytes and vascular tissues. These pathways contribute to essential physiological processes like immune response modulation and cellular communication.
Mutations in the FUT2 gene affect susceptibility to gastrointestinal diseases and infections like norovirus and Helicobacter pylori infection. The secretor status determined by FUT2's activity connects to Crohn’s disease where alterations in intestinal microbiota and H antigen expression occur. Fucosylation differences also link FUT2 to cystic fibrosis where enzyme malfunction affects pathogen adhesion and clearance alongside CFTR the cystic fibrosis transmembrane conductance regulator protein.