Abcam, ab177246, Anti-DMTF1 antibody

Size: 200µL
Goat Polyclonal DMTF1 antibody. Suitable for WB and reacts with Mouse, Rat, Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human DMTF1 aa 600-650.
Key facts
Host species:Goat,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human, Mouse, Rat,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human DMTF1 aa 600-650. The exact immunogen used to generate this antibody is proprietary information.Q9Y222,
Specificity:ab177246 is expected to recognize both reported isoforms (NP_066968.3; NP_001135798.1). Reported variants represent identical protein: NP_066968.3, NP_001135799.1.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab177246 is purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide., Storage buffer-pH: 7.3Preservative: 0.02% Sodium azideConstituents: 99% Tris buffered saline, 0.5% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
DMTF1 also known as Cyclin D-binding Myb-like transcription factor 1 is a transcription factor with a mass of approximately 120 kDa. It plays an important role in cell cycle regulation by interacting with cyclin D. DMTF1 expression is found in multiple tissues with higher levels notable in the prostate and colon. It exerts its mechanical function mainly in the nucleus where it binds to DNA sequences to modulate the transcription of its target genes.
Biological function summary
DMTF1 influences the cell's response to stress and arrest signals affecting cell proliferation and apoptosis. It acts as part of a transcriptional regulatory complex that involves other proteins such as p14ARF. This association allows DMTF1 to modulate tumor suppressor pathways. Such activity is important for maintaining cellular integrity and preventing uncontrolled cell growth that characterizes cancer.
Pathways
DMTF1 integrates into key regulatory networks such as the p53 and E2F pathways. In the p53 pathway DMTF1 interacts with other proteins such as MDM2 reinforcing the cell's defense mechanisms against DNA damage. Through the E2F pathway DMTF1 affects the expression of genes controlling cell cycle progression. These pathways link DMTF1 closely to the mechanisms that determine cell fate decisions in response to environmental cues.
DMTF1 shows a significant connection to cancers including lung and prostate cancer. Abnormal activity of DMTF1 can disrupt normal cell cycle control leading to tumorigenesis. Its interaction with proteins like p14ARF and MDM2 further exemplifies its involvement in cancer development. Understanding these interactions allows for deeper insights into potential therapeutic targets for these diseases.