Abcam, ab177958, Anti-ACSL1 + ACSL6 antibody [EPR13499]

Size: 20µL / 100µL / 1mL
Rabbit Recombinant Monoclonal ACSL1 antibody. Suitable for IHC-P, WB and reacts with Human, Recombinant fragment - Human samples. Cited in 18 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR13499,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purity-Tissue culture supernatant, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ACSL1 and ACSL6 are members of the acyl-CoA synthetase long-chain family. ACSL1 is also known as Acyl-CoA synthetase 1 with a mass of approximately 78 kDa. ACSL6 goes by the name Acyl-CoA synthetase 6. These enzymes convert free long-chain fatty acids into their active form acyl-CoA. ACSL1 is expressed in tissues like liver heart and adipose tissue while ACSL6 shows expression in brain and leukocytes. The activity of these enzymes is essential for lipid metabolism and energy production processes.
Biological function summary
The acyl-CoA synthetase functions as a gatekeeper in cellular lipid metabolism. Both ACSL1 and ACSL6 belong to a multi-enzyme complex involved in lipid modification processes. ACSL1 supports triglyceride synthesis and beta-oxidation of fatty acids. This role impacts energy homeostasis and lipid signaling. ACSL6 on the other hand participates in the formation of the myelin sheath in neurons and also influences neuronal differentiation through its action on fatty acid substrates.
Pathways
The enzymatic actions of ACSL1 and ACSL6 integrate into critical metabolic pathways. ACSL1 plays a role in the beta-oxidation pathway working in conjunction with enzymes like CPT1 to facilitate the transportation of acyl-CoA into mitochondria. ACSL6 is involved in the synthesis of myelin basic protein through the regulation of fatty acid availability. These enzymes also have connections to the peroxisome proliferator-activated receptor (PPAR) signaling pathway which controls the expression of genes related to lipid metabolism.
ACSL1 and ACSL6 have roles in metabolic and neurological diseases. ACSL1 is linked to metabolic diseases such as insulin resistance and type 2 diabetes as impaired lipid metabolism can affect insulin signaling pathways. ACSL6 associates with neurological disorders including schizophrenia due to its role in membrane lipid composition in neurons. The relationship of ACSL6 with proteins like myelin basic protein in the central nervous system underlines its importance in maintaining normal cognitive functions.