Abcam, ab178554, Anti-Tensin 3 antibody

Size: 100µg
Rabbit Polyclonal Tensin 3 antibody. Suitable for IHC-P, ICC/IF and reacts with Human, African green monkey samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human TNS3.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human, African green monkey,
Applications:ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human TNS3. The exact immunogen used to generate this antibody is proprietary information.Q68CZ2

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Tensin 3 also known as TNS3 is a cytoskeletal protein with a mass of approximately 150 kDa. It functions mechanically as part of the actin cytoskeleton network. The protein is involved in linking actin filaments to integrin receptors at focal adhesions playing a significant role in the dynamics and stability of cell movement. Tensin 3 is expressed in a variety of tissues including the lung liver and intestine indicating its broad functional relevance across different cell types.
Biological function summary
This protein contributes to the regulation of cell adhesion migration and organization. Tensin 3 often associates in complexes with other tensin family members such as Tensin 1 and Tensin 2 to perform its functions. These complexes help in the remodeling of the extracellular matrix and influence cell shape. Through interactions with these proteins Tensin 3 regulates signals that are essential for the maintenance of tissue architecture and integrity.
Pathways
Tensin 3 plays an important part in integrin signaling and cell motility pathways. It interacts closely with proteins involved in these pathways such as vinculin and talin. The integrin-mediated pathways where Tensin 3 is active are critical for processes like cell migration and wound healing. Furthermore through these pathways Tensin 3 connects cellular signaling cascades to mechanical forces within cells facilitating proper cellular response to environmental changes.
Involvement of Tensin 3 is significant in certain cancers like lung cancer and fibrotic diseases. Overexpression of Tensin 3 has been linked to cancer cell invasion and metastasis. In fibrotic conditions its dysregulation affects normal tissue repair often leading to excessive scarring. In both contexts Tensin 3 interacts with signaling proteins like focal adhesion kinase (FAK) which further amplifies its effects on disease progression and tissue pathology.