Abcam, ab178691, Anti-AAMP antibody [EPR12369]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal AAMP antibody. Suitable for WB, ICC/IF, Flow Cyt (Intra) and reacts with Human, Mouse, Rat samples. Cited in 2 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR12369,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:ICC/IF, WB, Flow Cyt (Intra)See reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
AAMP also known as angio-associated migratory cell protein is a small protein with a molecular mass of approximately 45 kDa. It is expressed in various tissues including endothelial cells and fibroblasts. The protein interacts with actin-binding proteins and plays a part in cytoskeletal dynamics. It supports cellular processes by influencing cell migration and vascular organization.
Biological function summary
The protein contributes to angiogenesis by promoting the migration and proliferation of endothelial cells necessary for new blood vessel formation. It is not part of a larger complex but still interacts with other proteins involved in the remodeling of the extracellular matrix. AAMP aids in cell adhesion which affects tissue repair and development.
Pathways
AAMP participates in the angiogenic signaling pathway. It interacts with other proteins such as integrins to mediate cellular responses to growth factors like VEGF (vascular endothelial growth factor). This coordination ensures proper vascular development and function. The protein integrates into pathways that control the actin cytoskeleton further contributing to motility and structure of cells.
AAMP shows relevance to cancer and cardiovascular disease. Its role in angiogenesis connects it to tumor growth where increased blood supply can promote cancer progression. Additionally AAMP's interaction with VEGF links it to cardiovascular disorders where aberrant vascular growth is a concern. As such AAMP may serve as a potential target in therapeutic strategies addressing these conditions.