Abcam, ab179948, Anti-RAB4B antibody - N-terminal

Size: 200µL
Rabbit Polyclonal RAB4B antibody. N-terminal. Suitable for WB, IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human RAB4B aa 1-100 conjugated to Keyhole Limpet Haemocyanin.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human RAB4B aa 1-100 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.P61018

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.09% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
RAB4B also known as Ras-related protein Rab-4B is a small GTPase with a molecular mass of approximately 24 kDa. This protein plays a mechanical role in controlling intracellular vesicle trafficking particularly involved in endosomal recycling. It facilitates the movement of membrane-bound vesicles within cells impacting various cellular processes. RAB4B is mostly expressed in tissues such as brain testis and kidney suggesting specialized roles in these regions.
Biological function summary
RAB4B mediates the sorting and recycling of receptors from the early endosome back to the plasma membrane or to other cellular destinations. As a member of the Rab protein family it often associates with protein complexes that include its effectors and other small GTPases. This network facilitates its role in maintaining cellular homeostasis and contributing to the traffic of cargo proteins to their intended cellular compartments.
Pathways
RAB4B is a significant participant in pathways such as the endocytosis pathway and receptor recycling. In these pathways it closely interacts with other proteins like RAB11A and RAB5 where they coordinate functions in sorting and recycling of endocytic vesicles. RAB4B assists in transitioning cargo from early endosomes to recycling endosomes or returning them to the cell surface therefore impacting cellular signal transduction and nutrient uptake.
Researchers have seen potential links between RAB4B dysregulation and neurological disorders as well as certain cancers. Aberrations in RAB4B expression or function might affect endosome dynamics contributing to disease progression. In certain cancers for example the altered trafficking of membrane receptors can drive tumor growth and metastasis possibly interacting with proteins like EGFR which is important for cell proliferation and survival.