Abcam, ab180137, Anti-TPTE antibody [EPR11867(2)] - N-terminal

Size: 20µL / 100µL / 1mL
Rabbit Recombinant Monoclonal TPTE antibody. N-terminal. Suitable for IHC-P, Flow Cyt (Intra), mIHC and reacts with Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR11867(2),
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, mIHC, Flow Cyt (Intra)See reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TPTE (Transmembrane Phosphatidylinositol 3-phosphatase and Tensin homolog) functions as a phosphatase involved in dephosphorylation of phosphoinositides. The transmembrane protein is also referred as TPIP (TPTE and PTEN homologous Inositol lipid Phosphatase) and has a molecular mass around 65 kDa. It shows expression in the liver prostate and testis tissues. TPTE can modulate signaling cascades through hydrolyzing phosphoinositides affecting downstream intracellular pathways.
Biological function summary
TPTE proteins play roles in phosphoinositide signaling and influence cellular processes like proliferation and survival. It functions similarly to the PTEN phosphatase which is part of a larger signaling network controlling cellular functions. The presence of TPTE in certain tissues suggests it also contributes to tissue-specific roles possibly involving phosphoinositide metabolism.
Pathways
TPTE influences the Akt signaling pathway by modifying phosphoinositide levels. This pathway is essential in regulating cell growth and survival involving interaction with proteins such as PI3K. Also TPTE connects to apoptosis signaling through modulating lipid phosphatase activity affecting proteins like PIP3 that play a role in survival pathways.
Researchers studied TPTE's potential connection to prostate cancer and its similarities to PTEN might provide insight into its role in tumor suppression. Aberrant function or expression of TPTE may parallel issues with PTEN impacting phosphoinositide signaling and contributing to oncogenesis. Furthermore TPTE-related studies also suggest relevance in metabolic disorders due to its enzyme activity that could influence insulin signaling pathways.