Abcam, ab180138, Anti-AP3M2 antibody [EPR12965] - N-terminal

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal AP3M2 antibody. N-terminal. Suitable for WB, ICC/IF, Flow Cyt (Intra) and reacts with Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR12965,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:Flow Cyt (Intra), ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purity-Tissue culture supernatant, Storage buffer-Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
AP3M2 also known as Adapter-Related Protein Complex 3 Mu 2 Subunit is a protein that plays a critical role in intracellular trafficking processes. It has a molecular mass of approximately 50 kDa. This protein is expressed in various tissues and is significantly abundant in the nervous system. AP3M2 forms part of the AP-3 complex which is essential for protein sorting and transport from the trans-Golgi network to endosomes and lysosomes.
Biological function summary
AP3M2 contributes to the regulation of membrane protein localization. It acts as part of the AP-3 complex working together with other subunits to facilitate vesicle formation and cargo selection for transport. The AP-3 complex is an adaptor protein complex that functions in the clathrin-independent transport pathway important for lysosomal protein sorting. AP3M2's function ensures proper cellular compartmentalization and distribution of lysosomal enzymes and membrane proteins.
Pathways
AP3M2 functions in the context of both the endocytic and secretory pathways. Within these pathways the protein partakes alongside proteins like VPS41 and HPS1 contributing to vesicular trafficking and organelle biogenesis. In the endocytic pathway AP3M2 helps in the transport of cargo to lysosomes affecting protein degradation and recycling while in the secretory pathway it assists in packaging lysosomal proteins for delivery to their proper cellular destinations.
AP3M2 is linked to Hermansky-Pudlak syndrome and neurodevelopmental disorders. Mutations in the genes encoding proteins of the AP-3 complex including AP3M2 are known to disrupt normal vesicular trafficking leading to symptoms observed in Hermansky-Pudlak syndrome a disorder characterized by albinism and bleeding issues. Furthermore alterations in AP3M2 function are also associated with neurological disorders linking to proteins like BI1 and AP3B1 affecting neuronal migration and synaptic function.