Abcam, ab180154, Anti-Spata18 antibody [EPR13704]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal Spata18 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 5 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR13704,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Spata18 also known as MitoPLD or spermatogenesis-associated protein 18 is an important protein that participates in mitochondrial quality control. This protein has a molecular mass of approximately 74 kDa. Researchers find Spata18 expressed mainly in the testes and other tissues such as heart and skeletal muscle. Spata18 acts on the mitochondria by mediating mitophagy which is the selective degradation of damaged or dysfunctional mitochondria thereby maintaining healthy cellular function.
Biological function summary
Spata18 exerts significant roles that ensure proper cell functionality. It initiates mitophagy by facilitating the mitochondria's removal when they become damaged preventing the accumulation of mitochondrial reactive oxygen species (ROS). Spata18 is known to function independently and does not typically require a larger protein complex to mediate its activity. Its expression and activity aggressively safeguard cellular integrity against oxidative stress by assuring the removal of compromised mitochondria.
Pathways
Spata18 is involved in the mitochondrial quality control and autophagy pathways. This protein significantly affects the pathways closely related to mitochondrial dynamics and function specifically promoting autophagic processes and mitochondria turnover. In association with other proteins like PINK1 and Parkin Spata18 operates within the mitophagy pathway to oversee the clearance of damaged mitochondria maintaining cellular health and bioenergetics balance.
Spata18's involvement in mitochondrial health can influence the onset and progression of conditions like Parkinson's disease and cardiac disorders. The protein's effective role in promoting mitophagy becomes important in neurodegenerative diseases as improper mitophagy and mitochondrial dysfunction appear as common features. In the context of Parkinson's disease Spata18 associates with Parkin and helps mitigate the effects of mitochondrial damage. Additionally its expression in cardiac tissues hints at potential links to cardiac disorders although further research is necessary to concrete its clinical significance.