Abcam, ab180507, Anti-ELKS antibody [EPR13777]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal ELKS antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 5 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR13777,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purity-Tissue culture supernatant, Storage buffer-Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The ELKS protein also known as ERC1 or Rab6-interacting golgin is about 120-150 kDa in mass and functions as a scaffold protein. It interacts with other proteins at synaptic sites playing an important part in the regulation of neurotransmitter release. ELKS mainly locates to the nervous system but is found in other tissues as well. This protein contains coiled-coil domains facilitating binding to various partners including RIM piccolo and liprin.
Biological function summary
ELKS contributes to synaptic vesicle priming and readiness for neurotransmission. Within its role ELKS becomes part of the presynaptic active zone complex critical for proper synapse functioning. This protein scaffolds various components bringing them together for efficient synaptic signaling. By stabilizing synaptic structures ELKS ensures rapid responses to neural stimuli important for normal neuronal communication and brain function.
Pathways
ELKS proteins become integral to the synaptic vesicle cycle and neurotransmitter release pathways. ELKS interacts with proteins such as RIM and Munc13 which are essential for vesicle docking and priming. These interactions help coordinate neuronal signaling and transmitter release connecting ELKS with the broader network of synaptic activity regulators. Key pathways such as the cAMP signaling pathway depend on this fine-tuned coordination to properly translate extracellular signals into cellular responses.
ELKS shows connections with neurological conditions such as epilepsy and schizophrenia. Abnormalities in ELKS function might disrupt neural circuitry contributing to these disorders. Changes in ELKS or related proteins like piccolo or bassoon can alter synaptic balance leading to disease states. Researchers continue to investigate how modulation of ELKS and its associated proteins may offer therapeutic avenues for such conditions.