Abcam, ab180855, Anti-Collagen VI alpha 2 antibody [EPR7889(N)]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal CO6A2 antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 5 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR7889(N),
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Species reactivity
Rat: We have preliminary internal testing data to indicate this antibody may not react with this species.
Please
contact us
for more information.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Collagen VI alpha 2 also known as COL6A2 or anti-collagen VI is a protein that is an essential component of the extracellular matrix. It forms a part of the collagen VI complex which is important for connective tissue stability and function. COL6A2 has a molecular mass of approximately 130 kDa. It is widely expressed in various tissues including muscle skin and the basement membrane of blood vessels indicating its diverse functional role.
Biological function summary
The COL6A2 protein contributes to maintaining tissue integrity and resilience. It forms a beaded filament structure as part of a collagen VI tetramer when combined with other alpha chains (alpha 1 and alpha 3). These interactions at the molecular level help to provide tensile strength and structural support to many tissues especially in muscle where it impacts elasticity and repair mechanisms.
Pathways
COL6A2 and its associated complex participate in the extracellular matrix organization and cell adhesion pathways. In these processes it interacts with proteins such as integrins and laminins which are important for cellular attachment and communication. Such pathways underline the significant roles COL6A2 plays in maintaining normal tissue architecture and cellular environments.
The COL6A2 protein has strong associations with conditions like myosclerosis and Bethlem myopathy. Mutations or dysfunctions in the COL6A2 gene can disrupt the extracellular matrix leading to musculoskeletal disorders. It also shows interactions with other proteins like dystrophin in these pathological states emphasizing its involvement in muscular integrity and function.