Abcam, ab180861, Anti-Ahsp antibody [EPR12319]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal AHSP antibody. Suitable for IHC-P, IP, WB and reacts with Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR12319,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IP, IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Species reactivity
Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species.
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contact us
for more information.
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb
patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4 Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.35% Sodium citrate, 0.17% Sodium chloride, 0.05% BSA, 0.03% EDTA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The AHSP protein also known as Alpha Hemoglobin Stabilizing Protein plays an important role in the stabilization of alpha-globin chains. This protein has a mass of approximately 11 kDa and is expressed in erythroid cells which are involved in red blood cell development and function. By binding to alpha-globin the AHSP protein assists in preventing harmful aggregation and degradation of these chains which is important in hemoglobin assembly and stability.
Biological function summary
AHSP protein assists in preventing the precipitation of excess free alpha-globin chains within erythroid cells. It acts as a chaperone guiding the proper folding of alpha-globin and facilitating the formation of hemoglobin. This protein does not work alone; it operates as a component of the erythrocytic protein maturation complex working closely with beta-globin during erythropoiesis to ensure effective hemoglobin production.
Pathways
The AHSP protein integrates into cellular processes by playing a role in the hemoglobin synthesis pathway. It is a part of the broader erythroid differentiation pathway and ensures effective erythrocyte maturation and function. AHSP protein is related to HBA1 and HBA2 proteins through these pathways as they are all important components during hemoglobin formation.
Malfunction or reduced expression of the AHSP protein links to various hemoglobinopathies such as beta-thalassemia and alpha-thalassemia. In these conditions imbalances in the globin chains cause abnormal erythrocyte formation and impaired oxygen transport. The AHSP protein connects to HBB and HBA1 proteins when considering these disorders as its stabilizing role influences the equilibrium between alpha- and beta-globin chains important for effective erythrocyte functionality.