Abcam, ab180890, Anti-IL36 beta/IL-1F8 antibody - C-terminal

Size: 100µg
Rabbit Polyclonal IL36 beta/IL-1F8 antibody. C-terminal. Suitable for WB, IHC-P and reacts with Human samples. Cited in 5 publications. Immunogen corresponding to Synthetic Peptide within Human IL36B.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human IL36B. The exact immunogen used to generate this antibody is proprietary information.Q9NZH7,
Specificity:ab180890 will only detect the longer isoform of IL36 beta / IL-1F8. ab180890 will not cross-react with IL36 alpha or IL36 gamma.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
IL-36 beta also known as IL-1F8 is a member of the interleukin 1 family. It has a mass of approximately 18 kDa. This protein mostly expresses in epithelial tissues including skin and lungs. It acts as a pro-inflammatory cytokine by binding to the IL-36 receptor leading to the activation and recruitment of immune cells to inflammatory sites. This process plays a significant role in host defense mechanisms and wound healing.
Biological function summary
IL-36 beta plays a role in modulating the immune response. It is not part of a complex but acts by enhancing the expression of chemokines and other cytokines. IL-36 beta interacts with inflammatory cells such as T cells and dendritic cells promoting increased inflammation. This mechanistic action makes it an important player in sustaining the inflammatory response and initiating a feedback loop that amplifies its effects.
Pathways
IL-36 beta participates in the NF-kB and MAPK signaling pathways. These pathways are critical to cell survival proliferation and cytokine production. Through these pathways IL-36 beta has interactions with other proteins like IL-1 alpha and IL-1 beta all part of the inflammatory response. This protein network links IL-36 beta to wider immune system activities and cellular responses to stress.
IL-36 beta is strongly associated with psoriasis and rheumatoid arthritis. In these conditions the overexpression of IL-36 beta can result in chronic inflammation. In psoriasis IL-36 beta works closely with proteins like IL-17A and TNF-alpha which also contribute to the pathogenesis of the disease. Similarly in rheumatoid arthritis increased IL-36 beta levels correlate with inflammation and joint damage establishing its role in exacerbating disease symptoms.