Abcam, ab180915, Anti-Betatrophin antibody - N-terminal

Size: 100µg
Rabbit Polyclonal Betatrophin antibody. N-terminal. Suitable for WB, IHC-P and reacts with Rat, Mouse, Human samples. Cited in 4 publications. Immunogen corresponding to Synthetic Peptide within Human ANGPTL8.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Rat, Human, Mouse,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human ANGPTL8. The exact immunogen used to generate this antibody is proprietary information.Q6UXH0,
Specificity:At least three isoforms of Betatrophin are known to exist (NP_061157, AAF76204 / EAW84186, EAW84185). ab180915 will detect the two largest isoforms of Betatrophin.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Betatrophin also known as ANGPTL8 or Lipasin is a protein involved in metabolic regulation. It has a molecular mass of approximately 22 kDa. The liver and adipose tissue mainly express this protein. Betatrophin plays a significant role in energy balance by influencing lipid metabolism making it an important factor in managing metabolic processes in the body.
Biological function summary
Betatrophin regulates the proliferation of pancreatic beta cells which are important for insulin production. It does not form part of a larger protein complex. Its expression can increase in response to metabolic demands linking it closely with the mechanisms of energy utilization and storage.
Pathways
Betatrophin interacts closely with lipid metabolism and glucose homeostasis. It influences the insulin signaling pathway and is interconnected with the regulation of triglyceride levels. In the context of these pathways betatrophin collaborates with proteins like ANGPTL3 to modulate lipid breakdown and storage playing an important part in metabolic balance.
Betatrophin is associated with Type 2 diabetes and obesity. Its role in inducing pancreatic beta cell proliferation makes it a point of interest for managing insulin resistance a common feature of diabetes. Proteins like ANGPTL4 also interact with betatrophin influencing lipid metabolism and linking to disorders such as obesity. Understanding betatrophin's function and regulation offers potential therapeutic targets for these metabolic diseases.