Abcam, ab180946, Anti-COPE antibody [EPR12579]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal COPE antibody. Suitable for IHC-P, WB, ICC/IF, Flow Cyt (Intra) and reacts with Human samples. Cited in 3 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR12579,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, Flow Cyt (Intra), ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The COPE protein also known as Coatomer Protein Complex Subunit E is a component of the COPI coatomer complex. This protein roughly weighs approximately 34 kDa and is present in the Golgi apparatus where it takes part in vesicle formation processes. COPE is expressed in numerous cell types highlighting its importance in intracellular transport mechanisms and maintaining cellular organization.
Biological function summary
COPE plays a significant role in the retrograde transport of proteins from the Golgi back to the endoplasmic reticulum being part of the larger COPI complex. The COPI coatomer complex operates in conjunction with other coat proteins like clathrin to ensure vesicle trafficking and membrane dynamics. This mechanism is essential for membrane recycling protein sorting and other cellular logistics.
Pathways
COPE is important in the secretory pathway. It interacts closely with other components like ARF1 a small GTPase that regulates coat assembly and disassembly to maintain efficient protein sorting. Moreover COPE's role intersects with the ER-to-Golgi transport pathway acting alongside proteins like Sec27 demonstrating its connection within a tightly regulated trafficking network essential for cellular function.
COPE’s malfunction associates with neurodegenerative diseases. Disruption in its role in vesicular trafficking can lead to protein aggregation disorders like Alzheimer's disease where protein accumulation becomes pathogenic. COPE interaction with proteins such as APP (Amyloid Precursor Protein) becomes evident in the pathology of Alzheimer's showcasing its importance in disease progression.