Abcam, ab181048, Anti-MRO antibody [EPR12158]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal MRO antibody. Suitable for IP, WB and reacts with Human, Rat, Mouse samples. Cited in 2 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR12158,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
MRO also known as Maestro is a protein with a molecular mass of approximately 36 kDa. The MRO gene encodes this protein and it plays a role in transcriptional regulation. MRO shows expression mainly in testicular tissue suggesting its involvement in reproductive processes. Researchers detect its presence largely in the developing testes where it may influence the maturation and differentiation of germ cells.
Biological function summary
The MRO protein influences pathways involved with reproductive development. It associates with other proteins to form complexes that affect gene expression regulation in germ cells. MRO has been identified as a factor in sex determination and differentiation. It interacts with various transcription factors to modulate the activity of genes essential for the formation and maintenance of spermatogonial stem cells.
Pathways
The MRO protein integrates into the sex determination and reproductive development pathways. It has ties to the WNT signaling pathway an important pathway for developmental processes. In these pathways MRO interacts with key proteins like SOX9 a critical factor in testis formation and DMRT1 which is involved in sex differentiation. This interaction network allows MRO to influence the development of the male reproductive organs.
MRO relates closely to infertility and disorders of sexual development. Researchers have linked aberrant expression of the MRO protein to issues in spermatogenesis which can lead to male infertility. Additionally MRO's interactions with other proteins such as NR5A1 implicated in disorders of sexual development highlight its potential role in these conditions. Through these associations MRO represents a notable target for understanding and potentially mitigating male reproductive health issues.