Abcam, ab181071, Anti-PPP2R2D antibody [EPR13624]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal PPP2R2D antibody. Suitable for WB and reacts with Mouse, Rat, Human samples. Cited in 2 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR13624,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The PPP2R2D protein also known as B regulatory subunit of phosphatase 2A (B55-Delta) is a part of the protein phosphatase 2 (PP2A) complex. It is an important element of the holoenzyme PP2A with an approximate molecular mass of 55 kilodaltons. This protein is expressed widely in human tissues including the brain and liver. PPP2R2D functions by regulating PP2A activity affecting various substrates and controlling the dephosphorylation process.
Biological function summary
PPP2R2D plays a role in cell cycle regulation and apoptosis. As a regulatory subunit of the PP2A complex it modulates the enzyme’s activity and substrate specificity. This control makes PPP2R2D important in the mitotic spindle checkpoint facilitating proper chromosome segregation. Its influence on cell cycle arrest and apoptosis emerges from its ability to target several key signaling molecules thereby ensuring proper cell function and survival.
Pathways
The PP2A complex containing PPP2R2D is integral to the MAPK/ERK and PI3K/AKT pathways. Through these pathways PPP2R2D influences cellular processes like growth differentiation and survival. Related proteins in these pathways include RAF and AKT which interact with PP2A peptides to stabilize the signaling environment. PPP2R2D's functionality ensures the pathways remain balanced enabling cells to maintain normal physiological functions.
Aberrant expression or mutation of PPP2R2D associates with cancers and neurodegenerative diseases. In cancer altered PP2A activity often linked with related proteins such as MYC contributes to uncontrolled cell proliferation. Similarly in neurological conditions like Alzheimer's disease the dysregulation of PP2A-related processes can lead to tau hyperphosphorylation highlighting deficiencies in the apoptotic pathways. Understanding PPP2R2D's role can therefore highlight potential therapeutic targets for these conditions.