Abcam, ab181234, Anti-ELMO1 + ELMO2 antibody [EPR13567]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal ELMO2 antibody. Suitable for WB and reacts with Human, Recombinant fragment - Human samples. Cited in 3 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR13567,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purity-Tissue culture supernatant, Storage buffer-Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ELMO1 and ELMO2 are proteins that play a role in intracellular signaling and cytoskeletal organization. ELMO1 is approximately 82 kDa in mass while ELMO2 is slightly smaller at around 80 kDa. These proteins are expressed in various tissues including the brain heart and lymphoid tissues. ELMO1 and ELMO2 interact with Dock180 a guanine nucleotide exchange factor to modulate cell morphology and migration by controlling actin cytoskeleton dynamics.
Biological function summary
ELMO1 and ELMO2 facilitate the regulation of cell migration phagocytosis and apoptosis. They are parts of a larger protein complex involving Dock180 and Rac1 contributing to the reorganization of the actin cytoskeleton. The ELMO-Dock180 complex acts as a critical mediator for the Rac signaling pathway affecting how cells respond to external signals that guide movement and cell survival.
Pathways
ELMO1 and ELMO2 participate in signaling pathways like the Rac1 pathway and the PI3K/Akt pathway. Through interactions with Rac1 these proteins regulate cytoskeletal rearrangements essential for various cellular processes including movement and immune cell function. ELMO1 and ELMO2 also connect with PI3K influencing the PI3K/Akt signaling cascade that is involved in cell growth and survival.
ELMO1 and ELMO2 have implications in cancer and autoimmune diseases. Studies link ELMO1 to increased susceptibility to systemic lupus erythematosus. Altered expression of ELMO2 is associated with cancer progression highlighting its potential as a therapeutic target. In cancer the interaction between ELMO proteins and Rac1 can enhance cell migration contributing to metastasis.