Abcam, ab181245, Anti-UGT3A1 antibody [EPR13723]

Size: 10µL-TRIAL / 100µL / 1mL
Rabbit Recombinant Monoclonal UGT3A1 antibody. Suitable for IHC-P, IP, WB, ICC/IF and reacts with Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR13723,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, IP, WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
UGT3A1 also known as UDP-glucuronosyltransferase 3A1 is an enzyme involved in the process of glucuronidation which adds glucuronic acid to substances aiding in their solubility and excretion from the body. This enzyme has a molecular mass of approximately 60 kDa. UGT3A1 is primarily expressed in the liver with some expression in other tissues such as the kidney and intestine. It acts by conjugating a variety of lipophilic compounds including drugs toxins and endogenous compounds like hormones and bilirubin facilitating their elimination.
Biological function summary
This enzyme plays an important role in detoxification and metabolism processes. UGT3A1 is part of the larger UDP-glucuronosyltransferase family which participates in phase II of drug metabolism. It does not function individually but as a homodimer offering structural support for catalytic activity. By making hydrophobic molecules more water-soluble UGT3A1 reduces their biological activity and assists in their removal from the body maintaining homeostasis.
Pathways
UGT3A1 is integral to the glucuronidation pathway a critical phase II metabolic process. This pathway is essential for the clearance of a wide range of substrates including therapeutic drugs and endogenous substrates. UGT3A1 interacts with the cytochrome P450 family which primarily deal with phase I of drug metabolism. Together they constitute a comprehensive metabolic framework essential for biotransformation of many xenobiotics and endogenous substances.
UGT3A1 has been associated with altered drug metabolism potentially influencing drug clearance and leading to adverse drug reactions. Additionally variations in UGT3A1 activity might contribute to disorders involving hormone imbalances due to its role in hormone glucuronidation. Polymorphisms in UGT3A1 gene may impact its expression and function linking it indirectly with CYP3A4 another pivotal enzyme in drug metabolism affecting overall pharmaceutical efficacy and safety.