Abcam, ab181853, Anti-SCGB3A2 antibody [EPR11463]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal SCGB3A2 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 14 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR11463,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SCGB3A2 also recognized as uteroglobin-related protein 1 (UGRP1) is a small secreted protein with a molecular mass around 10 kDa. It is mainly expressed in the epithelial cells of the respiratory tract notably the lungs where it plays a role in modulating immune responses. In terms of structure SCGB3A2 shares similarities with other secretoglobin family members indicating conserved functional motifs. Its expression is tightly regulated and reflects its involvement in maintaining respiratory health.
Biological function summary
SCGB3A2 acts as an anti-inflammatory agent that modulates immune cell activity and cytokine signaling within the lungs. It does not form known protein complexes but interacts with other immune mediators to reduce inflammation. Furthermore SCGB3A2 has roles in cell proliferation and repair mechanisms especially in response to lung injury. Its interaction with various cytokines supports tissue regeneration and homeostasis making it important in maintaining lung function.
Pathways
SCGB3A2 interacts in immune regulatory pathways significant in lung tissue. Notably it participates in pathways related to the suppression of inflammatory cytokine production and has a working relationship with proteins such as IL-10 and TGF-beta that mitigate excessive immune reactions. These interactions exhibit roles in the regulation of immune responses and the promotion of tissue repair making SCGB3A2 part of important biological processes that protect lung integrity.
SCGB3A2 is linked to conditions such as asthma and chronic obstructive pulmonary disease (COPD) where inflammation plays an important role. Alterations in SCGB3A2 expression correlate with disease severity suggesting its potential as a biomarker. Its relationship with TGF-beta is of particular interest as dysregulation of this protein contributes to fibrotic changes in lung tissue. Studies continue to explore how modulating SCGB3A2 levels may influence disease progression and treatment outcomes in inflammatory lung disorders.