Abcam, ab181994, Anti-RWDD1 antibody [EPR13715(B)]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal RWDD1 antibody. Suitable for IP, WB, Flow Cyt (Intra) and reacts with Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR13715(B),
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:Flow Cyt (Intra), WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purity-Tissue culture supernatant, Storage buffer-Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
RWDD1 also known as RWD domain-containing protein 1 is a protein with a molecular mass of approximately 12 kDa. This protein is expressed in various tissues including the brain liver and kidney. Mechanically RWDD1 interacts with other proteins through its RWD domain which is a conserved region facilitating protein-protein interactions. This domain helps RWDD1 participate in cellular processes by serving as a regulatory subunit in protein complexes.
Biological function summary
RWDD1 influences cellular activities due to its role in modulating protein degradation pathways. It is part of protein complexes that are involved in tagging proteins for degradation. This modulation affects many cellular processes such as cell cycle control and stress responses. The protein may work closely with proteasomal subunit proteins suggesting it has a specific function in maintaining cellular protein homeostasis.
Pathways
RWDD1 is actively involved in the ubiquitin-proteasome system which is a significant pathway for protein degradation. It interacts with proteins involved in ubiquitination processes which tag proteins for breakdown. Additionally RWDD1 plays a role in cellular response pathways to oxidative stress through associations with proteins like Nrf2 a well-known regulator of the antioxidant response.
Dysregulation of RWDD1 may link to cancer and neurodegenerative diseases. Abnormal RWDD1 function can lead to impaired protein degradation contributing to the accumulation of damaged or misfolded proteins a common feature in these conditions. Associations with proteins such as p53 in cancer and links to tau proteins in Alzheimer’s disease highlight its potential involvement in disease mechanisms.