Abcam, ab182141, Anti-Prostaglandin D Synthase (Lipocalin)/PDS antibody [EP12357]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal Prostaglandin D Synthase (Lipocalin)/PDS antibody. Suitable for WB, ICC/IF, IHC-P and reacts with Human samples. Cited in 15 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EP12357,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Prostaglandin D Synthase (Lipocalin) also known as PGDS or PDS is an enzyme that catalyzes the conversion of prostaglandin H2 to prostaglandin D2. It plays an important mechanical role in prostaglandin metabolism and has a mass of approximately 20 kDa. This protein is prominently expressed in the central nervous system heart and male genital organs. Its alternate name is lipocalin-type prostaglandin D synthase highlighting its membership in the lipocalin family. Notably it is abundant in cerebrospinal fluid and seminal plasma.
Biological function summary
This protein PDS participates in various physiological processes including inflammation and sleep regulation. It operates independently and is not typically part of larger protein complexes. PGDS contributes to the homeostasis of biological membranes and acts as a neuromodulator in the brain. Its function extends to mediating the actions of the prostaglandin D2 it produces affecting processes like allergic reactions and maintaining normal reproductive physiological functions.
Pathways
PGDS engages with key biological processes by being part of the MAPK signaling pathway and the arachidonic acid cascade. These pathways contribute to inflammation and immune response regulation. PGDS interacts specifically with other proteins along these pathways such as cyclooxygenases (COX-1 COX-2) which are important in the initial creation of prostaglandin H2. Its role in signaling elucidates its involvement in both central and peripheral biological activities.
PGDS links to conditions such as sleep disorders and allergic diseases. The production of prostaglandin D2 by PGDS can exacerbate symptoms of certain allergic responses including asthma. Furthermore PGDS involvement in sleep regulation can relate to narcolepsy. In these conditions it interacts with other proteins involved in prostaglandin signaling such as COX enzymes which are targeted by certain therapeutic interventions.