Abcam, ab182647, Anti-CaMK2 beta gamma delta (phospho T287) antibody

Size: 100µL
Rabbit Polyclonal KCC2B phospho T287 antibody. Suitable for WB, ICC/IF, IHC-P and reacts with Rat, Human samples. Cited in 18 publications. Immunogen corresponding to Synthetic Peptide within Human CAMK2B phospho T287 conjugated to Keyhole Limpet Haemocyanin.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Rat, Mouse, Human,
Applications:ICC/IF, WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human CAMK2B phospho T287 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.Q13554

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab182647 was purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatography using non-phosphopeptide., Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CaMK2 beta gamma delta also known as calcium/calmodulin-dependent protein kinase II is a multifunctional enzyme critical in cellular signaling. It consists of multiple isoforms such as alpha beta gamma and delta with specific focus on the beta gamma delta variants. The molecular weight varies depending on the isoform generally around 50 to 60 kDa. These isoforms are expressed in various tissues like the brain heart and skeletal muscle where they mediate calcium-dependent signal transduction processes.
Biological function summary
These isoforms play a pivotal role in translating calcium signals into cellular responses. They are part of a larger heteromeric complex that includes other CaMK2 subunits forming a holoenzyme that orchestrates intricate cellular mechanisms. Through autophosphorylation at key residues CaMK2 beta gamma delta regulate synaptic plasticity in neurons modulate cardiac contractility and contribute to skeletal muscle function.
Pathways
Several mechanisms integrate calcium/calmodulin signaling mediated by CaMK2 beta gamma delta. This enzyme group is significant in the calcium/calmodulin pathway and also intersects with the MAPK/ERK pathway. These pathways involve proteins such as calmodulin and ERK facilitating signal transduction and cellular output specificity which guide processes like learning and memory in the brain and trophic responses in cardiac tissues.
Dysregulation of CaMK2 beta gamma delta is associated with neurological and cardiac diseases. The targets contribute to the pathophysiology of Alzheimer's disease where aberrant kinase signaling affects synaptic functions potentially involving proteins like amyloid-beta. Moreover in cardiac hypertrophy disruption in CaMK2 signaling impacts heart muscle remodeling often interacting with proteins such as phospholamban linking calcium handling anomalies to disease progression.