Abcam, ab183032, Anti-TBR1 antibody [EPR8138(2)]

Size: 100µL / 1mL
Anti-TBR1 antibody [EPR8138(2)] (ab183032) is a rabbit monoclonal antibody detecting TBR1 in Western Blot, IHC-P, IHC-Fr, ICC/IF . Suitable for Human, Mouse, Rat . - Biophysical QC for unrivalled batch-batch consistency - Over 10 publications
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR8138(2),
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:IHC-P, WB, ICC/IF, IHC-FrSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
What is this antibody validated in?
Anti-TBR1 antibody [EPR8138(2)] (ab183032) is a rabbit recombinant monoclonal antibody and is validated for use in Western Blot (WB), Immunohistochemistry (IHC-P), Immunohistochemistry (IHC-Fr), Immunocytochemistry/immunofluorescence (ICC/IF) in Human, Mouse, Rat samples.
What is the molecular weight of TBR1?
Anti-TBR1 [EPR8138(2)] (ab183032) specifically detects a band for TBR1 (UniProt: Q16650) at a molecular weight of 74kDa.
Trusted by the scientific community
Anti-TBR1 [EPR8138(2)] (ab183032) was first used in a scientific publication in 2014 and has been cited over 10 times in peer-reviewed journals.
Reviewed by scientists
Anti-TBR1 [EPR8138(2)] (ab183032) has over 5 independent reviews from customers.
Trial sizes available!
Test your antibody or perform pre-screening before committing to a larger quantity. Sold in 10µl.
Discover our selection of trial-size antibodies
Other related products
We have a range of other formats of antibody clone [EPR8138(2)] also available for your convenience: ab183032, Carrier free -
ab239000
, Alexa Fluor® 594 -
ab311740
, Alexa Fluor® 568 -
ab313019
, Alexa Fluor® 555 -
ab313222
, Alexa Fluor® 488 -
ab314472
, Alexa Fluor® 647 -
ab314473
, Alexa Fluor® 750 -
ab321264
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TBR1 also known as T-Box Brain 1 is a transcription factor important for neuronal development. It weighs about 74 kDa. This protein is strongly expressed in the cerebral cortex during prenatal stages where it plays a role in regulating gene expression. TBR1 influences the differentiation and migration of cortical neurons which is critical for proper brain development.
Biological function summary
TBR1 influences neuronal differentiation through its function as a transcription factor. It binds to specific DNA sequences to regulate gene expression required for neuronal identity and function. TBR1 is part of a larger transcriptional complex that includes other proteins like CASK and TBR2 contributing to the maturation of cortical neurons. TBR1's role in these processes highlights its significance in neuronal circuit formation in the cerebral cortex.
Pathways
TBR1 is involved in the Wnt signaling and the reelin pathway which are both essential for normal brain development. In the Wnt signaling pathway TBR1 interacts with proteins such as LEF1 to influence cell fate decision and pattern formation. In the reelin pathway TBR1 work along with proteins like Reelin itself to regulate neuronal positioning promoting the correct layering of the cortex.
TBR1 has strong associations with autism spectrum disorders and intellectual disabilities. Mutations in TBR1 disrupt its role in gene regulation during brain development leading to the aforementioned neurological conditions. TBR1 also interacts with FOXP2 a protein involved in language and speech linking it further to communication-related aspects of these disorders.