Abcam, ab183171, Recombinant Human Paralemmin-1 protein

Size: 100µg
Recombinant Human Paralemmin-1 protein is a Human Full Length protein, in the 1 to 387 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE, Mass Spec.
Key facts
Purity:>85% SDS-PAGE,
Expression system:Escherichia coli,
Tags:His tag N-Terminus,
Applications:SDS-PAGE, Mass SpecSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:O75781,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 8Constituents: 10% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, 0.32% Tris HCl, 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

Product details:
This product was previously labelled as Paralemmin

Properties and Storage Information:
Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Paralemmin-1 also known as PALM is a lipid-anchored protein linked to the plasma membrane and involved in cellular processes that regulate cell shape and plasticity. It has a molecular weight of approximately 42 kDa. This protein expresses mainly in the brain particularly in regions like the hippocampus suggesting its significant role in neural cell function. Some data also note its presence in other tissues like the kidney and testis but at much lower levels compared to neural tissue.
Biological function summary
Paralemmin-1 plays a role in cellular membrane dynamics and structure. It assists in the stabilization of filopodia and participates in the regulation of neurite outgrowth both critical in neural development and maintenance. Although not a well-defined complex member Paralemmin-1 interacts with other proteins involved in cytoskeletal reorganization highlighting its importance in cellular morphology.
Pathways
Some studies point out that Paralemmin-1 associates with signaling cascades controlling actin cytoskeleton rearrangement particularly the Rho GTPase pathway. This protein interfaces with small GTPases like Cdc42 or Rac1 that drive changes in cell shape and motility directly linking it to the regulation of actin dynamics. Such interactions highlight its involvement in pathways integral to cell structure and signaling.
Deficits in Paralemmin-1 function have correlations with neurological disorders such as autism spectrum disorders (ASD) and intellectual disability. Pathologies like these show altered neuronal connectivity and synaptic plasticity areas where Paralemmin-1's role becomes important through its interaction with proteins like synaptic adhesion molecules. These associations point to Paralemmin-1 as a potential target for understanding and possibly modifying the progression of these neurological conditions.