Abcam, ab183310, Anti-C19orf2 antibody [SP215] - C-terminal

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal C19orf2 antibody. C-terminal. Suitable for Flow Cyt (Intra), IHC-P and reacts with Rat, Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:SP215,
Isotype:IgG,
Carrier free:No,
Reacts with:Rat, Human,
Applications:Flow Cyt (Intra), IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A/G, Purification notes-Purified from TCS by protein A/G., Storage buffer-pH: 7.6Preservative: 0.1% Sodium azideConstituents: PBS, 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The protein C19orf2 also known as Myeloid Leukemia Single-stranded DNA-binding Protein (MLSBP) has a molecular mass of approximately 25 kDa. This protein is expressed in various tissues with a particularly high presence in myeloid cells. Mechanically C19orf2 binds to single-stranded DNA and RNA due to its presence in the cell nucleus implicating its involvement in nucleic acid interactions and regulation.
Biological function summary
The protein engages in processes concerning genomic stability and the proper function of the DNA repair system. C19orf2 can interact as a part of a larger protein complex involved in recognizing and binding to abnormal DNA structures. This involvement suggests its participation in maintaining genomic integrity especially in myeloid cells which are important for the immune system's defense mechanisms.
Pathways
The C19orf2 protein integrates into the DNA damage response pathway. This pathway includes proteins like ATM and ATR which initiate signals in response to DNA damage. C19orf2 may therefore contribute to modulating these signals ensuring a proper response to genotoxic stress. Additionally C19orf2 plays a role in the myeloid differentiation pathway interacting with factors like PU.1 influencing the maturation and function of myeloid cells.
The dysfunction or aberrant expression of C19orf2 has been linked to acute myeloid leukemia (AML) and other hematopoietic disorders. Structural changes or expression levels of this protein might correlate with the proliferation and survival of leukemic cells. Furthermore C19orf2's relation to DNA repair pathways implicates its relevance in conditions associated with defective DNA repair processes potentially involving proteins like BRCA1 in hereditary breast and ovarian cancer syndromes.