Abcam, ab183504, Anti-PSS-2 antibody [EPR14663] - C-terminal

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal PSS-2 antibody. C-terminal. Suitable for IP, WB and reacts with Human samples. Cited in 3 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR14663,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
PSS-2 also known as Phospholipid Scramblase 2 functions mechanically as a lipid scramblase enzyme. It mediates the bidirectional movement of phospholipids across the bilayer of cellular membranes facilitating the collapse of lipid asymmetry. PSS-2 has a molecular weight of approximately 37 kDa. It is expressed in various tissues with significant presence in the liver which indicates its importance for lipid metabolism in this organ.
Biological function summary
Phospholipid scramblase 2 contributes to lipid homeostasis and membrane dynamics. PSS-2 forms complexes with several membrane proteins playing a role in processes such as apoptosis and cell signaling. By facilitating phospholipid translocation PSS-2 helps maintain cellular membrane composition which is critical for membrane integrity and function. This activity impacts cellular processes including cell shape motility and interaction with the environment.
Pathways
The activity of phospholipid scramblase 2 integrates into lipid metabolism and apoptotic pathways. Within the lipid metabolism pathway it cooperates closely with fatty acid-binding proteins to regulate lipid distribution and metabolism. Its involvement in the apoptotic pathway partners with caspases where it contributes to phosphatidylserine externalization an important apoptosis signal. This coordination places PSS-2 as a significant player in maintaining cellular health.
Dysregulation of phospholipid scramblase 2 associates with liver disorders and cardiovascular disease. Alterations in PSS-2 expression relate to non-alcoholic fatty liver disease due to its central role in hepatic lipid metabolism. Furthermore the interaction with proteins such as annexins links PSS-2 to cardiovascular health as these interactions influence thrombosis and inflammation. Understanding PSS-2's contributions in these contexts could lead to potential therapeutic targets for managing these conditions.