Abcam, ab183854, Anti-CDYL2 antibody

Size: 100µL
Rabbit Polyclonal CDYL2 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Fragment Protein within Human CDYL2 aa 1-400.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human CDYL2 aa 1-400. The exact immunogen used to generate this antibody is proprietary information.Q8N8U2

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: PBS, 20% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CDYL2 also known as Chromodomain Y-like protein 2 is a protein with a molecular mass around 65 kDa. It shares similarity with CDYL1 and belongs to the chromodomain family which suggests involvement in chromatin-related functions. CDYL2 is expressed widely across different tissues but shows higher expression levels in the brain and testes. The presence of chromodomain indicates potential for recognizing histone modifications allowing influence over chromatin structure and gene expression.
Biological function summary
CDYL2 serves essential roles in gene regulation and chromatin remodeling. The protein often acts as a transcriptional co-repressor contributing in the control of gene expression through its association with larger protein complexes. It interacts with histone methyltransferases and deacetylases helping to establish a repressive chromatin environment which impacts gene silencing. Furthermore CDYL2's involvement in these complexes suggests a contribution to developmental processes as well as cellular differentiation.
Pathways
CDYL2 interacts significantly within the chromatin modification and neuronal gene regulation pathways. The protein plays a part in H3K9 and H3K27 methylation pathways influencing gene repression through these epigenetic marks. It demonstrates interaction with proteins like G9a and EZH2 both of which are involved in histone methylation underlining its role in maintaining chromatin modification balance. Such associations emphasize CDYL2's contribution to regulating genetic expression patterns in various cellular processes.
CDYL2 links particularly to cancer and neurodevelopmental disorders. Its dysregulation can contribute to oncogenesis due to altered gene silencing and chromatin remodeling where it may interact with PRC2 complex proteins like EZH2 enhancing neoplastic cell proliferation. Additionally aberrations in CDYL2 expression are associated with neurological conditions such as intellectual disabilities where its interaction with chromatin modifiers can affect neuronal maturation and function. Understanding CDYL2's role in these disorders enhances insights for potential therapeutic approaches.