Abcam, ab184467, Anti-SHCBP1 antibody [EPR18843]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal SHCBP1 antibody. Suitable for IP, WB and reacts with Mouse, Rat, Human samples. Cited in 6 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR18843,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SHCBP1 also known as SHC SH2-Domain Binding Protein 1 is a 72 kDa protein involved in cell cycle regulation. This protein exhibits a significant role in the interaction with the SHC1 adaptor protein influencing the signaling pathways activated by receptor tyrosine kinases. SHCBP1 shows high expression in tissues with active cell division such as the testis and several cancer cell lines. Its localization within cells includes both the cytoplasm and nucleus indicating diverse functional roles.
Biological function summary
SHCBP1 aids in processes fundamental to cell proliferation and differentiation. It does not operate alone but participates in larger protein complexes that modulate cell division events. By interacting with other signaling molecules SHCBP1 becomes an important player in mitotic spindle assembly and cytokinesis. Its presence in complexes highlights its interaction with additional proteins which regulates the progression of the cell cycle.
Pathways
SHCBP1 resides in pathways linked to the regulation of mitosis and cell proliferation. This protein plays an important role in the PI3K/Akt signaling pathway which is pivotal for cell growth and survival. Additionally ties to proteins like PLK1 and Aurora B further emphasize SHCBP1's integration into cell cycle regulation networks. These interactions ensure proper cellular responses to growth signals and accurate chromosome segregation during mitosis.
SHCBP1 connections to cancer and infertility are notable. In several types of cancer overexpression of SHCBP1 associates with tumor progression and poor prognosis often through its interaction with oncogenic proteins like Cyclin D1. In cases of male infertility dysregulation of SHCBP1 impacts spermatogenesis due to its essential role in cell cycle and division. Understanding these associations offers potential pathways for therapeutic interventions targeting SHCBP1-related mechanisms.