Abcam, ab184555, Anti-SDS3 antibody [EPR15000]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal SDS3 antibody. Suitable for WB, Flow Cyt (Intra) and reacts with Human samples. Cited in 2 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR15000,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:Flow Cyt (Intra), WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SDS3 also known as SAP30 binding protein (SAP30BP) is a protein with a molecular weight of about 46 kDa. This protein is expressed in various tissues notably in the nucleus of cells. Mechanically SDS3 functions as a transcriptional regulator playing an essential role in chromatin remodeling and gene expression. It is a part of histone deacetylase complexes where it helps modulate the structural conformation of chromatin affecting DNA accessibility.
Biological function summary
SDS3 exerts important roles by being a component of the Sin3a corepressor complex. This complex is responsible for the repression of transcription through histone modification specifically deacetylation which leads to chromatin condensation. In this way SDS3 contributes to silencing specific genes which can influence cell differentiation and proliferation. Its interactions within the complex contribute to the regulation of diverse genes vital for cellular homeostasis.
Pathways
SDS3's interactions intervene in the transcriptional repression pathways and cell cycle regulation pathways. Involvement in these pathways showcases its role in maintaining proper cell division and controlling gene expression timing. SDS3 is closely related to other proteins like histone deacetylases HDAC1 and HDAC2 which participate in deacetylation activities that repress transcription and modify chromatin structure to restrict gene accessibility.
SDS3 has been linked to various cancers due to its role in regulating genes that control cell proliferation and survival. Abnormal expression or function of SDS3 can lead to inappropriate transcriptional repression of tumor suppressor genes contributing to unchecked cell growth. Additionally SDS3 is associated with neurodegenerative disorders due to its role in gene expression regulation in neural cells. In these conditions SDS3 may interact with other proteins such as SIN3A and RBBP4 further impacting gene expression profiles.