Abcam, ab184569, Anti-ARHGEF6 antibody [EPR11700(2)]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal ARHGEF6 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 3 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR11700(2),
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ARHGEF6 also known as alpha-PIX acts as a guanine nucleotide exchange factor (GEF) that specifically activates Rho GTPases by facilitating the exchange of GDP for GTP. Its molecular mass is approximately 98 kDa. The protein mainly expresses in various tissues like the brain and immune system cells such as B and T lymphocytes. ARHGEF6 plays a central role in controlling the cytoskeleton and cell morphology by influencing actin polymerization and cell adhesion.
Biological function summary
ARHGEF6 contributes to cellular signaling pathways that regulate cytoskeletal dynamics. It forms part of the PIX–PAK complex collaborating with PAK kinases. Through its interaction with these proteins ARHGEF6 influences cellular processes like cell migration and immune responses. Its regulation and activity can affect how cells communicate and respond to their environment playing an integral part in maintaining cellular architecture and processes.
Pathways
ARHGEF6 is essential in the regulation of the Rho GTPase signaling pathway and the integrin signaling pathway. This protein interacts with others like RAC1 and CDC42 which are vital in signal transduction processes. Through these pathways ARHGEF6 facilitates changes in cell shape motility and division responding to external signals that alter cellular dynamics.
Mutations in ARHGEF6 relate to X-linked mental retardation and other cognitive impairments. Its interaction with proteins like RAC1 and CDC42 can disrupt normal neural development when mutated impacting cognitive function. Additionally deregulation of ARHGEF6 has been observed in certain cancers where its signaling role may contribute to abnormal cell proliferation and migration. Understanding its involvement in these conditions offers potential pathways for intervention and therapy development.