Abcam, ab184571, Anti-Ramp4-2 antibody [EPR14338]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal Ramp4-2 antibody. Suitable for WB, ICC/IF, IHC-P and reacts with Human samples. Cited in 3 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR14338,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IHC-P, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Ramp4-2 also known as Ribosome-associated membrane protein 4-2 plays a role in the endoplasmic reticulum (ER) where it assists in protein synthesis and translocation. It is a small protein with a mass of approximately 8 kDa. Ramp4-2 is widely expressed in many tissues indicating its important function in cellular activities. This protein helps facilitate the movement of nascent polypeptides across the ER membrane ensuring proper folding and function of synthesized proteins.
Biological function summary
Ramp4-2 facilitates the assembly and stabilization of proteins as part of a ribosome-nascent chain complex. It ensures efficient translocation of polypeptides into the ER lumen where they fold and mature. By being part of this complex Ramp4-2 aids in maintaining the efficient functioning of protein translocation machinery thereby supporting overall protein homeostasis in cells. Its involvement in such cellular processes highlights its essential role in maintaining proper cellular function and protein balance.
Pathways
The Ramp4-2 protein engages with several other elements in the secretory pathway particularly the translocation pathway at the ER. It interacts closely with signal recognition particle (SRP) to guide ribosome-mRNA complexes to the ER. It also has connections to the complex involving Sec61 a translocon channel which facilitates polypeptide translocation into the ER. This participation indicates its importance in the ER stress response pathway acting alongside other components to ensure proper folding and processing of secreted and membrane-bound proteins.
Ramp4-2 has links to certain pathologies where protein misfolding or ER stress plays a role. Dysregulation or mutations in proteins associated with Ramp4-2 may contribute to neurodegenerative diseases such as Alzheimer's disease given the protein's integral role in protein folding and homeostasis. Likewise it may intersect with disorders related to metabolic dysregulation as it participates in pathways important for maintaining cellular proteostasis. Ramp4-2's interactions with proteins involved in these diseases highlight its potential relevance in therapeutic research and intervention strategies.