Abcam, ab184916, Anti-CTNNA3 antibody [EPR18307]

Size: 20µL / 100µL / 1mL
Rabbit Recombinant Monoclonal CTNNA3 antibody. Suitable for mIHC, IP, WB, IHC-P and reacts with Mouse, Human, Rat, Dog samples. Cited in 3 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR18307,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Dog, Human,
Applications:IP, IHC-P, mIHC, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CTNNA3 also known as alpha-T-catenin is a protein that plays a significant role in cellular adhesion. Alpha-T-catenin belongs to the catenin family and has a mass of approximately 100 kDa. It interacts with the actin cytoskeleton by binding to beta-catenin at adherens junctions which are important for maintaining cell structures. The expression of CTNNA3 occurs mainly in cardiac and muscle tissues an indicator of its specialized function in the structure and function of these cell types.
Biological function summary
The protein functions as an important component in cellular adhesion linking cadherins to the actin cytoskeleton which impacts tissue stability and integrity. CTNNA3 forms a complex with cadherin-catenin a structure vital for maintaining strong cell-cell adhesion. The protein ensures that cells within cardiac and skeletal muscles maintain their structural coherence during mechanical stress playing an integral role in muscle function and structural integrity.
Pathways
Alpha-T-catenin contributes to the regulation of Wnt signaling and adherens junctions assembly. These pathways involve cell cycle regulation cellular adhesion and migration. Within these pathways CTNNA3 interacts with other proteins like beta-catenin and cadherins coordinating cell behavior and maintenance processes. The protein's activity in the Wnt signaling pathway helps manipulate gene expression which ultimately affects cellular proliferation and differentiation.
Aberrations in CTNNA3 are linked to specific cardiac and muscle conditions such as arrhythmogenic right ventricular cardiomyopathy (ARVC) and muscular dystrophies. Disrupted function or expression of alpha-T-catenin can lead to compromised cardiac cell adhesion contributing to the development of ARVC. Furthermore mutations or downregulations of CTNNA3 are associated with alterations in beta-catenin interaction leading to impaired cellular functions contributing to disease pathogenesis.