Abcam, ab184925, Anti-Bcl G/BCL2L14 antibody [EPR17666]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal Bcl G/BCL2L14 antibody. Suitable for IP, WB, ICC/IF, Flow Cyt (Intra), IHC-P and reacts with Human, Mouse, Rat samples. Cited in 5 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR17666,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:WB, Flow Cyt (Intra), IHC-P, IP, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Bcl G also known as BCL2L14 is a protein part of the Bcl-2 family closely related to apoptosis regulation. It has a molecular mass of approximately 45 kDa. Bcl G expresses in various tissues with significant levels reported in the testis and lower levels observed in several other tissues like the brain liver and prostate. The protein exists in isoforms known as Bcl-G(L) and Bcl-G(S) with the former being more widely expressed.
Biological function summary
The function of this protein involves the regulation of apoptosis. Bcl G functions as a pro-apoptotic protein playing a role in cell death processes. Studies show that it can exist as part of larger complexes interacting with other Bcl-2 family proteins. This interaction usually influences mitochondrial pathways of apoptosis where Bcl G aids in mitochondrial membrane permeability changes leading to cell death.
Pathways
Bcl G significantly participates in the apoptosis pathway and the mitochondrial outer membrane permeabilization process. This protein interacts with several key regulatory proteins including Bcl-2 and Bax. These interactions modulate the release of cytochrome c from mitochondria a critical step in the intrinsic apoptosis pathway. Bcl G also aligns with the pathway for p53-mediated apoptosis further linking it to the cellular stress response.
Bcl G has associations with several forms of cancer. Research indicates a link between Bcl G expression and testicular cancer where it influences tumor progression and treatment response. In breast cancer Bcl G interacts with the well-known tumor suppressor p53 which suggests its role in tumor suppression and potential therapeutic target. Additionally mutations or altered expressions in this protein could disrupt normal apoptosis contributing to cancer development.