Abcam, ab184978, Anti-DIMT1L antibody

Size: 100µL
Rabbit Polyclonal DIMT1L antibody. Suitable for IHC-P, ICC, WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human DIMT1 aa 1-150.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IHC-P, ICCSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human DIMT1 aa 1-150. The exact immunogen used to generate this antibody is proprietary information.Q9UNQ2

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
DIMT1L also known as DIMT1 or Nsun5 is a 58 kDa protein involved in ribosomal RNA methylation. It functions as a methyltransferase introducing methyl groups at specific adenine residues in the small subunit ribosomal RNA (rRNA). The protein shows expression mainly in tissues with high rates of protein synthesis such as liver kidney and pancreas reflecting its role in ribosome biogenesis. Its widespread expression in proliferative tissues highlights its importance for cellular growth and division.
Biological function summary
The protein DIMT1L plays an important role in assembling the 40S ribosomal subunit a part of the eukaryotic 80S ribosome. As a methyltransferase this protein methylates adenine residues in rRNA influencing the ribosome's structural and functional integrity. It usually functions as a monomer not requiring large complexes to exert its effects. This methyltransferase activity is important for correct ribosome maturation which in turn affects protein synthesis capacity within cells.
Pathways
DIMT1L activity is integral to ribosome biogenesis and rRNA processing pathways. The protein interacts with components of the ribonucleoprotein complex to facilitate the final maturation steps of the 40S subunit. It associates with proteins like Nop14 which participate in similar rRNA processing pathways ensuring the fidelity of ribosome assembly. Its role in these pathways highlights the importance of ribosomal integrity for effective translation and overall cellular function.
Research links DIMT1L to certain cancers and growth defects. Aberrations in its expression or function can lead to dysregulation in ribosome production contributing to tumorigenesis. The protein sometimes connects to pathways involving tumor suppressor proteins like p53 where disruption can accelerate cancer progression. Beyond cancer other proliferative disorders might arise from alterations in DIMT1L-mediated processes highlighting the need for further exploration into its mechanistic impacts on human health.