Abcam, ab185453, Anti-TMEM79 antibody - N-terminal

Size: 100µL
Rabbit Polyclonal TMEM79 antibody. N-terminal. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human TMEM79 aa 1-100.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human TMEM79 aa 1-100. The exact immunogen used to generate this antibody is proprietary information.Q9BSE2

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TMEM79 also known as Mato is a transmembrane protein with an approximate mass of 42 kDa. This protein localizes mostly in the skin where it plays a role in maintaining skin barrier function. Expression of TMEM79 happens predominantly in keratinocytes which are the principal cells forming the epidermis. The protein comprises several transmembrane domains suggesting its role in cell membrane-related activities. Its mechanical action involves interactions at the cellular surface level important for skin cell communication and function.
Biological function summary
TMEM79 influences skin integrity and homeostasis. This protein does not typically form part of larger protein complexes but acts independently to safeguard skin barrier function. TMEM79 contributes to the structure and function of the stratum corneum the outermost layer of the skin which protects against environmental aggressors. Its activity helps regulate processes important for cellular adhesion and differentiation which are essential for maintaining healthy skin.
Pathways
TMEM79 participates in the processes tied to barrier homeostasis and skin differentiation. Its function is notably significant in the epidermal differentiation complex. TMEM79 interacts with key proteins such as filaggrin and loricrin both critical for maintaining the protective layer of the skin. These interactions assist in optimizing the skin's response to physical and chemical stresses ensuring an intact and functional epidermal barrier.
TMEM79 has been directly linked to atopic dermatitis and ichthyosis vulgaris. Variations in TMEM79 may lead to disrupted skin barrier function increasing susceptibility to these conditions. Research indicates interactions between TMEM79 and the protein filaggrin are essential. Filaggrin mutations have also been associated with atopic dermatitis highlighting the importance of TMEM79 in these dermatological disorders. Through its role and interactions TMEM79 proves to be a significant factor in skin health and disease.