Abcam, ab185459, Anti-FAM107A antibody

Size: 100µL
Rabbit Polyclonal FAM107A antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human FAM107A aa 50 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human FAM107A aa 50 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.O95990

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The FAM107A protein also known as DRR1 (Down-regulated in Renal Cell Carcinoma 1) is a small protein with a molecular mass of approximately 14 kDa. This protein is involved mechanically in modulating actin cytoskeleton dynamics and cell migration. It shows expression mainly in the brain and various other tissues. FAM107A plays a role in maintaining cellular architecture by interacting with actin filaments.
Biological function summary
FAM107A influences cell proliferation and differentiation processes by regulating cytoskeleton-associated signaling pathways. It does not form part of a large protein complex but interacts with other actin-binding proteins to exert its biological functions. This interaction is important for cellular responses to environmental changes impacting cell shape and movement.
Pathways
FAM107A participates specifically in the regulation of the cytoskeleton organization and the cell cycle pathways. It interacts with proteins like cofilin and profilin which are important for actin filament remodeling. The pathway involvement suggests FAM107A's role in modulating cytoskeletal dynamics that are critical for tissue development and repair.
Alterations in FAM107A expression have been associated with renal cell carcinoma and neuropsychiatric disorders. In renal cell carcinoma reduced FAM107A expression correlates with tumor progression and metastasis often connected to decreased cofilin activity. In neuropsychiatric disorders changes in actin dynamics due to FAM107A dysregulation are speculated to influence brain function potentially affecting proteins like synapsin which are involved in synaptic activity and plasticity.