Abcam, ab185483, Anti-Secretory lectin ZG16 antibody

Size: 100µL
Rabbit Polyclonal Secretory lectin ZG16 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human ZG16 aa 1-100.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human ZG16 aa 1-100. The exact immunogen used to generate this antibody is proprietary information.O60844

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Secretory lectin ZG16 also known as ZG16p (zymogen granule protein 16) plays an important role in the cell by binding carbohydrates. This protein has a molecular mass of approximately 16 kDa and is involved in glycan recognition showcasing its affinity for mannose. ZG16 is expressed mainly in the pancreas notably in the zymogen granules of acinar cells where it contributes to the packaging of secretory products.
Biological function summary
This lectin-based protein maintains the integrity and function of zymogen granules. ZG16 interacts with glycosaminoglycans facilitating the trafficking and localization of these granules within the cell. It is not known to be part of a larger protein complex but might interact transiently with other components of the zymogen granules. This molecular activity assists in efficient enzyme storage and secretion fundamental for normal pancreatic function.
Pathways
ZG16 plays a role in the cellular processes of exocytosis and protein trafficking. Its function aligns with the MAPK signaling pathway as well as the vesicle-mediated transport pathway. In these pathways ZG16's interaction with proteins like MIST1 and RabGTPase influences granule maturation and secretory pathways which are essential for the controlled release of digestive enzymes.
ZG16 links to conditions such as pancreatitis and cystic fibrosis where proper enzyme secretion is compromised. During pancreatitis inflammation affects ZG16 expression altering granule dynamics and impacting digestion. In cystic fibrosis although the primary defect lies in CFTR changes in ZG16 expression may contribute to malabsorption issues due to improper enzyme activation. Understanding the role of ZG16 in these diseases provides insights into potential therapeutic avenues targeting these proteins.