Abcam, ab185541, Anti-ZFY antibody [EPR11074]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal ZFY antibody. Suitable for WB, Flow Cyt (Intra) and reacts with Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR11074,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:Flow Cyt (Intra), WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.,
Specificity:ab185541 may cross-react with ZFX based on homology search showing these proteins (ZFX and ZFY) are 96% identical.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The ZFY protein also known as Zinc Finger Protein Y-linked is a transcription factor with a mass of approximately 69 kDa. It originates from the Y chromosome and is expressed mainly in male-specific tissues such as the testes. The protein contains C2H2-type zinc finger domains which facilitate its ability to bind DNA and modulate the transcription of specific genes. Its positioning on the Y chromosome links it directly to male-related biological processes.
Biological function summary
ZFY influences gene expression by binding to specific DNA sequences which impacts cellular development and differentiation. As a transcription factor it often works alone rather than as part of a larger complex. In certain contexts it plays a role in male sex determination and spermatogenesis suggesting its importance in regulating genes important for male germ cell development.
Pathways
ZFY plays a significant role in the sex differentiation pathway and spermatogenesis pathway. It interacts with other Y chromosome-encoded proteins like SRY which is important for initiating male sex determination. Moreover juxtaposing proteins such as SOX9 also engage in the pathways where ZFY exerts influence although ZFY mainly functions independently.
ZFY has connections with infertility in males and certain sex chromosome disorders. Researchers link defects or aberrant expression of ZFY to male infertility due to its critical role in spermatogenesis. Additionally it associates with Turner’s syndrome when aberrations in its expression occur highlighting its interaction with other Y chromosome-related proteins including TSPY.