Abcam, ab185943, Anti-SCG10 antibody [EPR15286]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal SCG10 antibody. Suitable for IP, WB and reacts with Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR15286,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SCG10 also known as Superior Cervical Ganglion 10 or Stathmin-like 2 functions mechanically as a microtubule destabilizing protein. It belongs to a larger family known as the stathmin family and has a molecular mass of approximately 21 kDa. Expression of SCG10 is mostly in the central nervous system with high levels found in neurons particularly during development and growth of axons. This specific distribution suggests a specialized role in neural processes.
Biological function summary
SCG10 plays an important role in neural growth by promoting microtubule dynamics. Its activity helps to regulate the assembly and disassembly of microtubules essential for maintaining the structure and function of growing neurons. SCG10 is not typically part of a larger complex; instead it acts alone to perform its microtubule-related tasks. This independent action allows for precise control over neural development and regeneration processes.
Pathways
SCG10 contributes significantly to pathways involving neural development and axonal transport. It frequently participates in the microtubule-dependent pathways that facilitate rapid changes in axonal architecture. Linked proteins such as tubulin and the stathmin family proteins collaborate in these pathways to modulate microtubule stability. This coordination underpins the efficient transport of cellular components necessary for nerve cell function and response.
SCG10 has associations with neurodegenerative conditions and neuroblastoma. Abnormal SCG10 expression or function can influence neuron health and survival potentially contributing to disorders like Alzheimer's disease. Furthermore alteration in SCG10 levels relates to neuroblastoma because of its role in neural cell growth. Its relationship with the protein Tau in neurodegenerative conditions highlights its importance in maintaining neuronal integrity and function.