Abcam, ab185944, Anti-TMEM30B antibody [EPR14409]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal TMEM30B antibody. Suitable for WB and reacts with Mouse, Rat, Human samples. Cited in 2 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR14409,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TMEM30B also known as CDC50B is a regulatory subunit of P4-ATPase flippases. This protein interacts with P4-ATPases to facilitate the transport of phospholipids from the outer to the inner leaflet of the plasma membrane. TMEM30B has a molecular mass of approximately 38 kDa. It expresses highly in brain tissue with some expression noted in the heart and skeletal muscles as well. Understanding its mechanical role helps us appreciate its importance in maintaining proper cell membrane function and integrity.
Biological function summary
TMEM30B serves as an essential component of the P4-ATPase complex playing a role in maintaining lipid asymmetry in cell membranes. This lipid asymmetry is critical for various cellular processes including vesicular trafficking and cell signaling. TMEM30B is involved in cellular processes such as neuronal development and synaptic function given its higher expression in brain tissue. The existence of TMEM30B within this complex helps maintain the delicate balance required for functional and structural stability of cell membranes.
Pathways
TMEM30B is involved in lipid metabolism and cellular homeostasis pathways. The protein's interaction with P4-ATPases like ATP8A2 plays a role in the maintenance of phospholipid distribution across the plasma membrane an important aspect of lipid metabolism. TMEM30B is also associated with the endocytosis pathway influencing how cells internalize substances and respond to external signals. It functions alongside proteins such as CDC50A in these pathways to ensure efficient cellular operations.
TMEM30B shows a relationship with neurological disorders including neurodevelopmental disorders and epilepsy. Abnormal expression or mutations in TMEM30B disrupt lipid asymmetry in neuronal cells impacting membrane fluidity and signaling leading to disease symptoms. In addition TMEM30B associates with Alzheimer's disease where it affects the amyloid precursor protein (APP) processing potentially contributing to plaque formation. Understanding these connections can lead to better therapeutic strategies targeting TMEM30B-related pathways and diseases.