Abcam, ab186426, Anti-GIPC3 antibody [EPR15315]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal GIPC3 antibody. Suitable for IP, WB and reacts with Human samples. Cited in 2 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR15315,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The GIPC3 protein also known as PDZ domain-containing protein GIPC3 is a member of the GIPC family. It has a molecular mass of approximately 36 kDa. This protein is expressed in many tissues but it shows higher expression levels in sensory organs such as the cochlea. GIPC3 plays a role in cellular processes through its interaction with PDZ domain-containing proteins which are important for various cellular signaling activities. By acting as an adaptor GIPC3 links different proteins together facilitating their functions within cells.
Biological function summary
GIPC3 is involved in cellular signaling pathways where it assists in protein trafficking and stability. It is part of larger protein complexes that regulate endocytic trafficking important for maintaining cellular processes. The interaction of GIPC3 with other PDZ domain-containing proteins indicates its involvement in organizing cell signaling networks. Additionally GIPC3 affects the molecular mechanisms by which cells respond to signals contributing to proper cellular function and response.
Pathways
GIPC3 is known to participate in the endocytic and PDZ-mediated signaling pathways. It plays a role in facilitating the internalization and trafficking of various signaling molecules. GIPC3 interacts with the insulin-like growth factor 1 receptor (IGF1R) within these pathways influencing cellular growth and differentiation. Furthermore it has connections with proteins such as GIPC1 and GIPC2 highlighting its involvement in cellular communication networks.
Mutations in GIPC3 have been associated with autosomal recessive non-syndromic hearing loss. This connection highlights its critical role in auditory function. Research also links GIPC3 to Usher syndrome a disorder affecting hearing vision and balance. Within these conditions GIPC3 interacts with proteins like harmonin and whirlin which are involved in maintaining sensory cell structure and function. Understanding GIPC3's role in these processes aids in developing targeted therapeutic strategies.