Abcam, ab186729, Anti-FANCB antibody [EPR15513]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal FANCB antibody. Suitable for IP, WB, Flow Cyt (Intra), IHC-P and reacts with Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR15513,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, Flow Cyt (Intra), IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
FANCB also known as Fanconi anemia group B protein plays an important role in the DNA repair mechanism. This target is part of the Fanconi anemia (FA) protein family and is approximately 101 kDa in mass. FANCB is expressed in various tissues but has a higher presence in those with rapidly dividing cells such as bone marrow and fetal liver. This protein maintains structural stability during DNA replication and repair by performing its mechanical function.
Biological function summary
FANCB interacts with other proteins as part of the FA core complex which includes eight other FA proteins. It facilitates the repair of interstrand DNA crosslinks a critical aspect of maintaining genomic integrity. FANCB contributes to the activation and monoubiquitination of FANCD2 and FANCI forming DNA repair foci necessary for correcting DNA damage. These actions highlight its integral role in genomic stability and stress response.
Pathways
The FANCB protein is part of the Fanconi anemia pathway which coordinates cellular responses to DNA damage. This pathway involves other proteins such as FANCA and FANCC which work together to initiate repair processes. Additionally FANCB contributes to the homologous recombination repair pathway by interacting with proteins like BRCA1 and RAD51 essential for repairing double-strand breaks in DNA providing a backup mechanism when routine repair mechanisms are stressed.
FANCB mutations can lead to Fanconi anemia a rare genetic disorder characterized by bone marrow failure and increased cancer risk. This protein along with FANCA and FANCJ influences the progression and severity of this condition. Moreover FANCB mutations have connections to certain cancers as they may contribute to genetic instability driving uncontrolled cell growth. These associations highlight the importance of understanding FANCB function to develop therapies targeting related diseases.