Abcam, ab186730, Anti-SSPN antibody [EPR15515]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal SSPN antibody. Suitable for WB and reacts with Mouse, Rat, Human samples. Cited in 2 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR15515,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Synaptophysin (SSPN) is a protein that functions mechanically as a cell membrane protein. It appears widely in various tissues but notably in skeletal muscle and the central nervous system. The approximate molecular mass of SSPN is 25 kDa. Commonly one finds it as a part of membrane structures in cells where it plays roles in maintaining membrane integrity and facilitating signal transduction.
Biological function summary
SSPN associates with the dystrophin-glycoprotein complex which plays important roles in the structural linkage between the extracellular matrix and the cytoskeleton. This association contributes to cellular stability and muscle function. SSPN is important for cellular communication impacting signal transduction processes and maintaining cellular architecture.
Pathways
The dystrophin-glycoprotein complex that includes SSPN is key in the mechanotransduction pathway where it translates mechanical stimuli into chemical signals. Additionally SSPN interacts with proteins like dystrophin helping transmit mechanical tension in the muscle tissue and caveolin which plays roles in signal transduction pathways. These interactions are pivotal for muscular responses and cellular signaling adaptations.
Mutations or disruptions in SSPN function link closely to muscular dystrophies such as Duchenne and Becker muscular dystrophies. These conditions also involve related proteins such as dystrophin highlighting the importance of SSPN in muscle health and disease. Moreover SSPN's association with the central nervous system suggests relevancy in neurodegenerative disorders although further research is needed to fully understand these connections.